DrugRepurposing Online is a proprietary database, created by Numedicus, for finding new uses for existing compounds, containing both existing and abandoned drugs. Importantly, it is differentiated from other attempts to link molecules, targets and diseases, by focussing functional, experimentally validated content. On-line access for registered users to this search engine for finding secondary uses for such compounds is available through this portal.
Levels of database access
There are various levels of access, both free (restricted) and premium; the latter is available either by paying or by contributing. Users can add new examples of drug repurposing and receive rewards which may be used to offset — either in part, or in full — subscriptions to the database. In this way, DrugRepurposing Online is a community of like-minded investigators, and also a gold standard crowdsourced resource for this most efficient and attractive strategy for medicinal innovation.
The database is populated with 4723 literature references, of which 1051 derive from prospective clinical studies or case reports, 237 from retrospective or case control analyses, 2075 are from pharmacological in vivo studies and 488 are from patents. The rest are in vitro studies or genomic associations.
The original Drugrepurposing Online database has recently been supplemented with access to information from the Guide to Pharmacology database (under a Creative Commons Attribution-ShareAlike 4.0 International License). Through this integration, Drugrepurposing Online has been supplemented with 9859 compounds (albeit, there is some overlap with existing information), and 19082 new interactions between compounds and mechanisms.
Patents as a secondary exclusivity driver for new repurposed medicinal products
Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes accelerated ageing Drug repurposing is often regarded as a cinderella child of new medicine discovery because ‘old drugs have expired [...]
Retrospective analysis does not equate to prospective efficacy in drug trials for brain cancer
A variety of observational studies have been performed with respect to glioblastoma multiforme, the most lethal form of brain cancer, and the use of sodium valproate, an antiepileptic drug. Patients [...]