DrugRepurposing Online is a proprietary database for finding new uses for existing compounds, containing both existing and abandoned drugs. On-line access for registered users to this search engine for finding secondary uses for such compounds is available through this portal.

Levels of database access

There are various levels of access, both free (restricted) and premium; the latter is available either by paying or by contributing. Users can add new examples of drug repurposing and receive rewards which may be used to offset -- either in part, or in full -- subscriptions to the database. In this way, DrugRepurposing Online is a community of like-minded investigators, and also a gold standard crowdsourced resource for this most efficient and attractive strategy for medicinal innovation.

Database content

This database contains 9040 compounds which have been either launched, registered or investigated, covering 441 indications, with 724 mechanisms. There are 2730 links between mechanism and indication, 688 links between compound and indication and 178 links between compound and mechanism -- so-called "off-target" effects. Overall this gives rise to 3596 repurposing opportunities for further consideration.

The database is populated with 4035 literature references, of which 909 derive from prospective clinical studies or case reports, 209 from retrospective or case control analyses, 1771 are from pharmacological in vivo studies and 432 are from patents. The rest are in vitro studies or genomic associations.

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