A variety of observational studies have been performed with respect to glioblastoma multiforme, the most lethal form of brain cancer, and the use of sodium valproate, an antiepileptic drug. Patients treated with sodium valproate for epilepsy have showed a improved outcome with respect to survival time and recurrence compared to patients treated with other antiepileptic...
Monthly Archives: February 2019
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Feb
Feb
In a recent analysis of the economics of pharmaceutical innovation, Grabowski and DiMasi calculated that out-of-pocket costs for a new chemical entity (NCE) were $1.395bn, compared to the costs for a ‘post-approval’ product of $466m. Accordingly, it may be possible to obtain three repurposed medicines for the investment in one new chemical entity. This is […]
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Feb
The antidiabetic sulfonylureas, which inhibit ATP-sensitive K+ (KATP) channels in pancreatic beta cells and stimulate insulin release in diabetes mellitus, mediate their effect on KATP channels via a high-affinity sulfonylurea receptor (SUR). But when looked at retrospectively in diabetic patients with ischemic stroke, patients treated with these drugs also seemd to be protected against stroke, […]